What is the HG breakthrough we co-published in Nature Communications?
This study provides scientific evidence linking 2 genes, GDF15 and IGFBP7, to HG. These genes provide the instructions to build the proteins GDF15 and IGFBP7 in the human placenta during pregnancy. The proteins are known to be important in the development of the placenta and in controlling appetite. We have done additional work presented at the ICHG (vimeo.com/260389622) showing that not only are these genes linked to HG, but also, the proteins are abnormally high in the blood from patients hospitalized with HG.
HER Foundation helps UCLA, USC and 23&Me link debilitating pregnancy illness to two genes
FINALLY A BREAKTHROUGH FOR women suffering from the severe pregnancy illness, hyperemesis gravidarum (HG). Many people remember Princess Kate Middleton being hospitalized during her first pregnancy due to the severity of the disorder. However, other women affected by the pregnancy illness have limited family size, quit their jobs or sadly felt so desperate due to the debilitating illness that they terminated wanted pregnancies. Many HG women describe the illness as something no one can truly understand unless they have endured it themselves. Instead of the joy every pregnancy should bring, HG women spend most of the 9 months suffering in silence unable to eat or simply keep water down.
The HER Foundation, researchers at UCLA and USC, and 23andMe, Inc. conducted the first genome-wide analysis of Hyperemesis Gravidarum (HG) and identified two genes associated with HG, which was published this week in Nature Communications. (https://www.nature.com/articles/s41467-018-03258-0). Continue reading
Hope you had a wonderful time with family this Christmas! Best wishes for 2018 from all of us at HER! Thank you to all who donated to #Give2HER to make this year a success!
Do you believe in our goal of improving HG management so moms & babies have a healthy future? DATA leads to PROGRESS!! So we need YOU – try our free iPhone app TODAY! Why is this app SO CRITICAL?? Imagine this… [See instructional demo!]
- Imagine slow research studies replaced by real-time data from the app being used to develop effective treatment protocols!!
- Imagine being able to easily communicate to your health professionals exactly what medications you took and how sick you truly are!
- Imagine seeing how much (or little) you’ve eaten and if your treatments are working after just 5 minutes each day using the app.
- Imagine getting alerts when your weight drops or you are getting dehydrated and need to go to the ER before your condition is serious!
- Imagine being reminded to take your meds and change your IV dressing if needed.
Imagine no more! This app will do all that and more! If we get enough participation and feedback, we can finalize this HG Care App project and moms enduring HG will finally have hope for real progress very soon! Progress means OUR CHILDREN won’t suffer as we have!
This app will NOT be completed without YOUR participation! This is a ONCE in a lifetime opportunity for the HG community thanks to #HERFoundation and #UCLA! Please join today!If you are not pregnant or using an iPhone, share this post and educate others on the CRITICAL need for this app. It’s NOW OR NEVER!!
The International Colloquium on HG in London (Oct 5-6) was a great success! Two presentations (1, 2) explained how ketones should not be required to be diagnosed with HG or given treatment. Some women are denied IV fluids if they do not have ketones.
What are ketones? They are produced when the body is starving and uses fat versus carbohydrates as fuel.
Ketones do not always correlate with weight loss or symptoms severity. They do predict a longer duration of hospitalization.
In response to the announcement of Catherine, Duchess of Cambridge’s third pregnancy and treatment for hyperemesis gravidarum (HG), the Hyperemesis Education and Research (HER) Foundation extends best wishes for the health of mother and baby during this joyful yet challenging time.
Distinct from “morning sickness” common in most healthy pregnancies, HG is characterized by weight loss, malnutrition, and dehydration due to severe vomiting and/or nausea. Severity and duration of symptoms vary, but HG remains the leading cause of hospitalization in early pregnancy and a debilitating medical condition that can have serious health consequences for both mom and baby. It is particularly threatening to mothers without immediate access to effective treatment and IV nutritional support.
“While the Duchess of Cambridge is undoubtedly receiving the proactive and knowledgeable care that has an enormous positive impact on her and the baby’s health, our hearts go out to her as she again experiences the disruption of health, work, and family life that many thousands of HG women endure each year.” said Kimber Wakefield MacGibbon, R.N., HER Foundation co-founder and director. “It is our hope that through increased funding for HG research, in addition to education, we can restore some of the pregnancy joy for mothers with HG, so they and their babies have a healthier future.”
The Duchess’s third pregnancy comes at a time of great promise and hope for HG women and families: Continue reading
UCLA Health is partnering with HER on the first HG app. It will release around September 1 for user testing and we need your help! It will only take about 5 minutes to input your symptoms and food/fluids each day. You must be pregnant, sick with nausea/vomiting, using an iPhone and apps, and speak English. See the full details below. If you don’t qualify, or are not currently pregnant, you can help by sharing this with your friends and on social media. If you are interested in trying out our new HG Care app, please contact Dr. Marlena Fejzo immediately at mfejzo @ mednet.ucla.edu.
What an exciting month for HG Awareness! From reaching and teaching docs at ACOG, the premiere OB conference, to HG Awareness Day on May 15, and the HER 5K Purple Bucket Run/Walk (with a 1 mile walk/run) on May 20th! The Purple Bucket Run is as much fun and awareness as it is fundraising for important genetics research to find a cause and cure for HG. Grant funding is rare for HG despite the devastating impact on families and the 1000’s of babies lost each year! Help us raise awareness and funding so more women and their children survive HG!