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Other Nutrients & Supplements

• Barley Green
• Half a lemon in hot water first upon rising and last thing at bedtime will help to clear the liver of the excess hormones.
• Glutamine and other GI mucosal protectants (see below)

Vitamins »

Glutamine and other GI mucosal protectants

Although we avoid recommending specific products, this one is very highly regarded in the complementary medical community. Personal experience has also found it extremely helpful with gastric ulcer support. It may be helpful in preventing excessive mucosal irritation and ulcers during HG. The following is excerpted from their product sheet. This product may ONLY be ordered by a licensed health care professional.

Tyler, Inc's (Integrative Therapeutics) Permeability Factors™ provides key nutrients for mucosal stabilization and gastrointestinal support. Defects in the mucosal barrier of the intestines can result in leakage of macromolecules and adventitious compounds into the general circulation and tissues.

L-Glutamine is conditionally essential nutrient utilized by the enterocytes of the small intestine for normal cellular concentration, and recovery from surgical or chemical insult. Glutamine efficiency has been shown to result in ulcer formation, muscle waiting and compromised immunity via degeneration of gut-associated lymphoid tissue (GALT). L-Glutamine is a precursor to endogenous glutathione production, and therefore plays an important role as a free-radical scavenger and anti-inflammatory.(1-6)

N-Acetlyl-D-Glucosamine (NAG) is a key component in the biosynthesis of the intestinal mucosa, which acts to protet the intestinal wall from contact with digestive enzymes ad acids, while allowing for the selective absorption of nutrients. Phosphatidylcholine has also been shown to protect and restore the gastrointestinal mucosa by strengthening the mucous-phopholipid layer.(7-13)

Gamma-oryzanol is a naturally offering extract of rice bran oil. Results of animals studies indicate gamma oryzanol provides localized protection of the gastrointestinal mucosa against ulcer formation, reduces hyperacidity and exerts potent antioxidants activity.(14-16)

Gama linolenic acid (GLA) from borage seed oil is a direct precursor for the synthesis of anti-inflammatory prostaglandins, especially prostaglandin E-1 (PGE-1). Both PGE-1 and GLA have been shown to protect the gastric mucosa against damage caused by exposure to gastrointestinal irritants. (19-24)

References

1. Wilmore, D.W., et al, The gut: A central organ after surgical stress. Surgery 104(5):917-23, 1988.
2. Klimberg, V.S., et al, Prophylactic glutamine protects the intestinal mucosa from radiation injury. Cancer. 1:66, (1):62-8, 1990.
3. Klein S., Glutamine: An essential nonessential amino acid for the gut. Gastroenterology. 99(1):279-81, 1990.
4. Korvath K, Jami M, Hill D, et al, Short-term effect of a complete but glutamine free oral diet on the small intestine. Gastroenterology. 106(4):A610.
5. Souba WW. Klimberg VS. Plumley DA, et al, The role of glutamine in maintaining a healthy gut and supporting the metabolic response to injury and infection. [Review] Journal of Surgical Research. 48(4):383-91, 1990.
6. Alverdy JC. Effects of glutamine-supplemented diets on immunology of the gut. Journal of Parental & Enteral Nutrition. 14(4 Suppl):109S-113S, 1990.
7. Glass GB. Slomiany, BL. Derangements of biosynthesis, production and secretion of mucus in gastrointestinal injury and disease. Advances in Experimental Medicine & Biology. 89:311-47, 1977.
8. Herp A, Borelli C, Wu AM. Biochemistry and lectin binding properties of mammalian salivary mucous glycoproteins. Advances in Experimental Medicine & Biology. 228:395-435, 1988.
9. Rhodes JM, Black RR. Savage A. Altered lectin binding by colonic epithelial glycoconjugates in ulcerative colitis and Crohn's disease. Digestive Diseases & Sciences. 33(11):1359-63, 1988.
10. Ryder SD, Smith JA, Rhodes JM. Peanut lectin: a mitogen for normal human colonic epithelium and human HT29 colorectal cancer cells. Journal of the National Cancer Institute. 84(18):1410-6, 1992.
11. Ghannoum MA, Abu-Elteen K, Ibrahim A, Stretton R, Protection against Candida albicans gastrointestinal colonization and dissemination by saccharides in experimental animals. Microbios. 67(271):95-105, 1991.
12. Sajjan S, Forstner JF. Characteristics of binding of Escherichia coli serotype 0157:H7 strain CL-49 to purified intestinal mucin. Infection & Immunity. 58(4):860-7, 1990.
13. Canty DJ, Zeisel SH. Lecithin and choline in human health and disease. [Review] [78 refs] Nutrition Reviews. 52(10):327-39, 1994.
14. Fukushi, T., Studies on edible rice bran oils, Part 3. Antioxidant effects of oryzanol. Rep. Hokaido Inst. Public Health. 16:111, 1966.
15. Fukushi, T., Studies on edible rice bran oils, Part 4. Comparison of the heat-resistant character between oryzanol and alpha-tocopherol. Rep. Hokaido Inst. Public Health. 16:115, 1966.
16. Yagi K, Ohishi N, Action of ferulic acid and its derivatives as anti-oxidants. Journal of Nutritional Science & Vitaminology. 25(2):127-30, 1979.
17. Okada, T., Yamaguchi, N., Antioxidative effect and pharmacology of oryzanol. Yakugaku (J. Jap. Oil Chem. Soc.). 32(6):305, 1983.
18. Kanno, H., Usuki, R., Kaneds, T., Antioxidative effects of oryzanol on thermal oxidation of oils. Nippon Shokuhin Kogyo Gakkaishi (J. Jpn. Soc. Food Sci. Technol.) 32(3):170,1985.
19. Hawkey, C.J., Synthesis of prostagladin E3, thromboxane B2 and prostglandin catabolism in gastritis and gastric ulcer. Gut., 27(12):1484-92, 1986.
20. Doyle, M.J., et al, In vivo assessment of precursor induced prostglandin release within the rat gastric lumen. Prostaglandins. 38(5):581-97, 1989.
21. Barre, D.E., Holub, B.J., The effect of borage oil consumption on human plasma lipid levels and the levels and the phosphatidylcholine and cholesterol ester composition of hgh density lipoprotein. Nutrition Research. 12:1181-1194, 1992.
22. Tarnawski, A, Hollander D, Stachura J, et al, Protection of the rat gastric mucosa against aspirin injury by arachidonic acid: a dietary prostaglandin precursor fatty acid. European Journal of Clinical Investigation. 19(3):278-90, 1989.
23. Tsukada H, Zielenski J, Mizuta K, et al, Prostglandin protection against ethanol-induced gastric injury: regulatory effect on the mucus glycoprotein metabolism. Digestion. 36(4):201-12, 1987.
    These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent and disease.

Updated on: Aug. 09, 2006