UCLA study finds no evidence linking anti-nausea drug to birth defects

A study published by UCLA and supported, in part, by the Hyperemesis Education and Research Foundation found no evidence linking Zofran to birth defects.

“What was really significant to me was that women with extreme morning sickness who took Zofran reported fewer miscarriages and terminations and experienced higher live birth rates,” Fejzo said. “Taking this medication helped them get through their pregnancies and gave them their desired outcome, a live birth.”
Marlena Fejzo, PhD

Source: UCLA Health
Read the full study or HER Foundation collaborative research.

“In this retrospective study, data on outcomes were collected on 1,070 pregnancies exposed to Zofran and compared to outcomes in two control groups, 771 pregnancies in women with a history of HG with no Zofran exposure and 1,555 pregnancies with neither a history of HG nor Zofran exposure. Heart defects were reported in five of 952 infants in the HG/Zofran-exposure group and in eight of the 1286 infants born to women who did not have HG and were not exposed to Zofran. Cleft palate was reported in one of 952 live births in the HG/Zofran-exposure group and in two of 1286 in the women who did not have HG and did not take Zofran.”

“This retrospective cohort study is part of a larger, ongoing investigation evaluating the genetics and epidemiology of HG. Eligible patients were primarily recruited through advertising on the Hyperemesis Education and Research Foundation Web site at www.HelpHer.org between 2007 and 2014.”

“This study suggests that having a history of HG, not the exposure to Zofran, may be associated with an increased risk of birth defects,” Fejzo said. “Women have to weigh the evidence of the efficacy of one of the most effective drugs for nausea and vomiting against the risk of birth defects. Women and their babies need nutrition during pregnancy, and if they have less nausea and vomiting that goal may be accomplished.”
Marlena Fejzo, PhD

Source: UCLA Health

 

One thought on “UCLA study finds no evidence linking anti-nausea drug to birth defects

  1. Hi
    Regarding the study about zofran and birth defects: in what pregnancy weeks did the pregnant women take the medication?
    I saw a statement on DrugWatch which stared that e.g. the Danish study result was not to be trusted since all women included in the study took the drug after w10, and therefore were outside the window for the development of birth defects.
    I am on my 8th pregnancy week, and this is my 3rd pregnancy with HG. It gets worse every time. I have previously been on prometazin (antihistamine), but I only found help from it during my first pregnancy. No other medicine has worked fo me.
    My doctor prescribed me ondansetron but I am really scare to start taking it. At the same time I am in a really poor way, and vomit 15-30times a day.
    I don’t know what the right answer is :(