"Research on HG's short- and long-term effects is desperately needed and needed now. We need to do more to find a cure for this disease that has such devastating effects on a growing number of soon-to-be mothers."
- Congressman Xavier Becerra (CA)
Currently the HER Foundation, in collaboration with UCLA and USC, is studying the Genetics of Hyperemesis Gravidarum (HG). These HG Researchers need your help regardless if you have had or have not had HG.
Why More Research Is Needed
Hyperemesis gravidarum (HG) was first recognized several centuries ago and was thought to be related to a physiological cause such as toxins, ulcerations, or infection. However, in the 20th century it was erroneously decided that HG was caused by psychological conflicts instead. Limited research and outdated theories have fostered this belief from generation to generation of health professionals, resulting in unnecessary suffering and financial loss for too many women and their families, not to mention unknown consequences for their unborn children.
Our Role in Research
The HER Foundation is a non-profit organization dedicated to educating others on the management of hyperemesis gravidarum (HG). It is our goal to increase awareness of available medical care and the potentially devastating consequences if untreated.
Research Findings (Collaborative projects of the HER Foundation & USC & UCLA)
Prevalence, Recurrence & Genetics:
- Genetic analysis of hyperemesis gravidarum reveals association with
intracellular calcium release channel (RYR2)
--Molecular and Cellular Endocrinology, 2016.
- Recurrence Risk of Hyperemesis Gravidarum.
-- J Midwifery Womens Health, 2011.
Change in Paternity and Recurrence of Hyperemesis Gravidarum.
-- The Journal of Maternal-Fetal and Neonatal Medicine, 2011.
Familial aggregation of hyperemesis gravidarum.
-- Am J Obstet Gynecol, 2010.
- High prevalence of severe nausea and vomiting of pregnancy and hyperemesis gravidarum among relatives of affected individuals.
-- Eur J Obstet Gynecol Reprod Biol., 2008
Aggregation of Hyperemesis Gravidarum
-- October 2001
Risks & Outcomes (Complications & Consequences)
- Analysis of pre- and post-pregnancy issues in women with hyperemesis gravidarum
-- Autonomic Neuroscience, 2016
- Ondansetron in pregnancy and risk of adverse fetal outcomes in theUnited States
-- Reproductive Toxicology, 2016
- Mortality Secondary to Hyperemesis Gravidarum: A Case Report
-- Women’s Health & Gynecology, 2015
- Neurodevelopmental delay in children exposed in utero to hyperemesis gravidarum
-- European Journal of Obstetrics & Gynecology and Reproductive Biology, 2015
- Intestinal obstruction is a rare complication
of ondansetron exposure in hyperemesis gravidarum
-- Reproductive Toxicology, 2015
- Psychiatric factors do not affect recurrence risk of hyperemesis gravidarum
-- Journal of Obstetrics and Gynaecology Research, 2015
- Antihistamines and other prognostic factors for adverse outcome in hyperemesis gravidarum. -- European Journal of Obstetrics & Gynecology and Reproductive Biolog, 2013
- Prenatal exposure to hyperemesis gravidarum linked to increased risk of psychological and behavioral disorders in adulthood.
-- Journal of Developmental Disorders of Health and Disease, 2011.
- Risk factors, treatments, and outcomes associated with prolonged hyperemesis gravidarum. The Journal of Maternal-Fetal and Neonatal Medicine, 2011.
Posttraumatic stress symptoms following pregnancy complicated by hyperemesis gravidarum. -- The Journal of Maternal-Fetal and Neonatal Medicine, 2011.
- Symptoms and Pregnancy Outcomes Associated with Extreme Weight Loss Among Women with Hyperemesis Gravidarum.
-- Journal of Women's Health, Dec. 2009 (PDF)
- Case Report: Patients with a history of hyperemesis gravidarum have similar symptoms during egg stimulation and develop ovarian hyperstimulation syndrome.
-- Fertility and Sterility, Nov. 2009 (PDF)
- Elective pregnancy termination in a large cohort of women with hyperemesis gravidarum.
-- Aug. 2007 (PDF)
- The psychosocial burden of hyperemesis gravidarum.
-- Journal of Perinatology, Nov. 2007 (PDF)
- Hyperemesis gravidarum: it is time to put an end to the misguided theory of a psychiatric etiology
-- SciVerse ScienceDirect, 2012
- Secular Trends in the Treatment of
-- American Journal of Perinatology, Nov. 2007
- Future Research Survey Executive Summary
-- May 2005
Research Presentation Posters:
Symptomatology and Outcomes of Women with HG as Reported in a Large Registry (PDF)
Familial Aggregation of HG (PDF)
- Research Presentation
Voluntary Termination in a Large Cohort of Women with Hyperemesis Gravidarum (PDF)
- Research Presentation
Secular Trends in the Treatment of Hyperemesis Gravidarum (PDF)
- Research Presentation
Extreme Weight Loss and Extended Duration of Symptoms Common in Hyperemesis Gravidarum (PDF)
Updated on: Oct. 29, 2016